|Title:||Non-Invasive Ventilation (NIV) Pre and Post ‘Kaftrio®’ at Beaumont Hospital Cystic Fibrosis (CF) Centre|
|Author(s):||L.Cullen A.Murphy M.Casey C.Gunaratnam N.G.McElvaney|
|Poster:||Click to view poster|
|Category:||CF and Pulmonary Infections|
|Abstract:||NIV is an accepted tool as a bridge to transplantation in people with CF (PWCF) with severe lung disease. Limited data exists for the effects of Kaftrio® in this group. |
The aim of this study was to examine the effects of ‘Kaftrio®’ in a small group of NIV dependent adults with severe CF.
Patient demographics and NIV data, including respiratory rate (RR), tidal volume (VT), minute ventilation (MV) and minutes of usage, for 4 patients were examined in the 3 months before and after initiation of ‘Kaftrio®’.
Statistically significant changes in FEV1% (p=0.0437), FVC% (p=0.0119), RR (p=0.0137) and MV (p=0.0420) were found. One patient discontinued use of NIV and oxygen (02), and 2 patients reduced their 02 requirements from 3L02 to 2L02 at night. Improvements in VT, minutes of usage, CF-ABLE score, BMI and weight were also found, however, they were not statistically significant.
This small study has demonstrated improvements in work of breathing and quality of life for PWCF with severe lung disease within months of starting Kaftrio®. We plan to monitor NIV data more closely and complete more frequent investigations in order for therapy to be adjusted and/or discontinued in an objective and timely manner.