Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma- A Single Center Review of the Diagnostic Approach

Title: Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma- A Single Center Review of the Diagnostic Approach
Author(s): Farrell AM , Farrell SA, Kennedy MP, Henry MT
Institution: Cork University Hospital
Poster: Click to view poster
Category: Lung Cancer/CF/ILD/Surgery
Abstract: Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a rare disease and diagnosis is difficult, often requiring multiple attempts at tissue sampling. The aim of this review was to evaluate the diagnostic pathway.

A retrospective review was preformed of patients diagnosed with pulmonary MALT lymphoma in a tertiary referral lung cancer center over 9 years. Ten patients were identified and each diagnostic and treatment approach was analyzed.

30% were diagnosed via transbronchial biopsy, two with the assistance of radial probe ultrasound guidance and one with transbronchial lung cryobiopsy of a predetermined CT-guided targeted segment. 70% were diagnosed following surgical biopsy. 40% had localized disease.

Diagnosis was not successfully achieved until a large sized tissue specimen was obtained. The implementation of novel bronchoscopy techniques can assist in reducing the number of invasive surgical procedures required to obtain a diagnosis. All cases should be discussed in a multidisciplinary setting prior to diagnostic attempts.