| Title: | The correlation of ILD MDT diagnosis with explant histopathology in transplant recipients. |
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| Author(s): | D O’Malley, M O’Callaghan, L Brown, A Fabre, MP Keane, C McCarthy |
| Institution: | St Vincents University Hospital |
| Poster: | Click to view poster |
| Category: | ILD |
| Abstract: | Interstitial lung disease (ILD) patients are a patient cohort increasingly requiring lung transplant, with current emphasis on identifying treatment options using multi-disciplinary team (MDT) discussion. We compared explanted histopathology of 14 patients with ILD with their pre-referral diagnosis to determine diagnostic accuracy of our referral pathway. A list of all patients with an ILD diagnosis referred for lung transplant from SVUH between 2010-2020 was obtained from a clinical database. Pre-transplant referral diagnosis was determined by clinical assessment, radiological imaging, lung biopsy and/or MDT discussion. Histopathological assessment of explanted tissue was performed with pathologist blinded to the pre-referral diagnosis. In 71% (n=10) of cases pre-transplant diagnosis fully correlated with explant histology. 14% (n=2) of cases partially correlated and 14% (n=2) did not correlate with any pre-referral findings, with only one of these four discussed at MDT. 83% correlation was seen in cases discussed at MDT, with biopsy facilitating pre-transplant diagnosis in difficult cases. The relatively high number of cases (almost 30%) that did not fully correlate with explant histopathology and improved figures seen with MDT discussion supports this pathway to enhance pre-transplant diagnostic accuracy. The possibility of progression of ILD phenotype over time encourages continued MDT discussion of cases awaiting transplant. |
